The Glycation Hypothesis of Atherosclerosis by Camilo A. L. S. Colaco

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The Glycation Hypothesis of Atherosclerosis

Author : Camilo A. L. S. Colaco
Publisher : Chapman & Hall
Published : 1997
ISBN-10 : 1570594449
ISBN-13 : 9781570594441
Number of Pages : 219 Pages
Language : en


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Results The Glycation Hypothesis of Atherosclerosis

Cross-Linking Theory of Aging: How Sugar Makes Us Age - Verywell Health - Cross-linking of skin protein collagen has been found to be partially responsible for wrinkles and other age-related skin changes, and researchers believe that cross-linking of protein the walls of the arteries account for atherosclerosis, or the hardening of arteries that increases your risk for heart attack and stroke, among other conditions
Glycation - an overview | ScienceDirect Topics - The glycation, AGE, or Maillard hypothesis identifies glucose as the culprit in diabetes, and proposes that diabetic complications result from accelerated Maillard reaction damage to tissue protein. ... but AGE modification of collagen can also contribute to atherosclerosis, nephropathy, and peripheral vascular disorders
The Glycation Hypothesis Of Atherosclerosis - Goodreads - The Glycation Hypothesis Of Atherosclerosis book. Read reviews from world's largest community for readers
Frontiers | Association of Advanced Glycation End Products With Lower - Aims: Advanced glycation end products (AGEs) were reported to be correlated with the development of diabetes, as well as diabetic vascular complications. Therefore, this study aimed at investigating the association between AGEs and lower-extremity atherosclerotic disease (LEAD).Methods: A total of 1,013 type 2 diabetes patients were enrolled. LEAD was measured through color Doppler
Macrophages in atherosclerosis: a dynamic balance - Nature - Atherosclerosis is a chronic inflammatory disease that arises from an imbalance in lipid metabolism and a maladaptive immune response driven by the accumulation of cholesterol-laden macrophages in
Atherosclerosis and glycation - PubMed - Atherosclerosis is the major cause of death in the industrialised world. Though much work on the pathogenesis of atherosclerosis points to 'oxidised' low density lipoprotein (LDL) as a key aetiological feature in the generation of the atherosclerotic plaque, the nature of this 'oxidised' LDL in vivo remains an enigma
Do glycated red blood cells cause vascular tissue damage ... - ResearchGate - Hi, Robert. While your thinking might be on the right track, glycation is just a sign of larger protein glycation due to increased levels of glucose in blood
The glycation hypothesis of atherosclerosis - Open Library - The glycation hypothesis of atherosclerosis by Camilo A. L. S. Colaco, 1997, Chapman & Hall, Landes Bioscience edition, in English
Atherosclerosis — An Inflammatory Disease | NEJM - Atherosclerosis is an inflammatory disease. Because high plasma concentrations of cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the principal risk
Glycation, carbonyl stress, EAGLEs, and the vascular ... - PubMed - The "glycation hypothesis'' has developed over the past 30 years, evolving gradually into a "carbonyl stress hypothesis'' and taking into account not only the modification of proteins by glucose, but also the roles of oxidative stress, a wide range of reactive carbonyl-containing intermediates (derived not only from glucose but also from lipids
Sugar and Age-Inducing Glycation | Atkins - Sugar and Age-Inducing Glycation; How it Works. Sugar and Age-Inducing Glycation ... A., Vlassara, H., Brownlee, M., "Hypothesis: Glucose as a Mediator of Aging," Journal of the American Geriatric Society, 33(9), 1985, pages 626-634. ... "Glycation and Oxidation: A Role in the Pathogenesis of Atherosclerosis," American Journal of
Glycation of paraoxonase 1 by high glucose instigates ... - Nature - Diabetes mellitus is usually associated with the development of atherosclerosis and nephropathy, which is characterized by endothelial dysfunction 1,d glycation end-products (AGEs) are a
Raquel López-Díez, PhD - Associate Research Scientist - LinkedIn - We tested the hypothesis that advanced glycation end products (AGEs) and their receptor (RAGE) block angiogenesis and blood flow recovery after hindlimb ischemia induced by femoral artery ligation
Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis - Early characterizations of endothelial cell dysfunction, in the context of atherogenesis, focused on a loss of anatomical integrity of the intima, as exemplified by the seminal "Response-to-Injury Hypothesis" of Ross and Glomset 7, which stimulated much fruitful activity in the field. As originally formulated, the Response-to-Injury
How Diabetes Drives Atherosclerosis -- ScienceDaily - Experts once believed that atherosclerosis, or hardening of the arteries, developed when too much cholesterol clogged arteries with fatty deposits called plaques. ... Glycation reactions cause the
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Frontiers | Glycation of LDL: AGEs, impact on lipoprotein function, and - Atherosclerosis is a complex disease, and there are many factors that influence its development and the course of the disease. A deep understanding of the pathological mechanisms underlying atherogenesis is needed to develop optimal therapeutic strategies and treatments. In this review, we have focused on low density lipoproteins. According to multiple studies, their atherogenic properties are
The link between diabetes and atherosclerosis - Lucia La Sala - Clinical relationships between diabetes and atherosclerosis are well established. The majority of the clinical and experimental data regarding the onset of diabetes complications are associated with atherosclerosis, suggesting that the impact of chronic hyperglycaemia might induce damage on vascular homeostasis, mainly attributable to the endothelium function
High Blood Sugar Linked To Aging And Disease - Diabetes In Control - Previous clinical studies have established that AGE increase atherosclerosis by glyco-oxidation of low density lipoproteins (bad cholesterol) and the promotion of vascular cell adhesion molecules (VCAM) on artery walls. ... 4 Colaco, Camilo, The Glycation Hypothesis of Atherosclerosis (Medical Intelligence Unit) May 1997. 5 Packer, Lester, p
Glycation and AGEs: Everything You Need to Know - Glycation differs from another common glycating process-where sugars attach to proteins and fats-called glycosylation. Glycosylation is an enzyme-directed site-specific process. ... This hypothesis has been aptly termed "fructositis ... AGEs are found in the arterial plaques of atherosclerosis, the well-known "hardening of the arteries"
Glycation - an overview | ScienceDirect Topics - These observations supported, for the first time at the molecular level, the hypothesis that non-enzymatic glycation of DNA could have adverse biological effects. ... Glycation and Atherosclerosis. Glycation refers to the irreversible binding of glucose with proteins and lipids and is an important factor in the pathogenesis of atherosclerosis
How hyperglycemia promotes atherosclerosis: molecular mechanisms - Both type I and type II diabetes are powerful and independent risk factors for coronary artery disease (CAD), stroke, and peripheral arterial disease. Atherosclerosis accounts for virtually 80% of all deaths among diabetic patients. Prolonged exposure to hyperglycemia is now recognized a major factor in the pathogenesis of atherosclerosis in diabetes. Hyperglycemia induces a large number of
Does Elevated Glucose Promote Atherosclerosis? Pros and Cons - Pros. • A large number of studies convincingly show detrimental effects consistent with proatherosclerotic actions of elevated glucose in endothelial cells, SMCs, and immune cells. Cons. • Cells in culture can exhibit metabolism different from that of cells in vivo. • Several cell culture studies show no effect of elevated glucose
JCM | Free Full-Text | Role of Advanced Glycation End Products on - The aim of this study was to evaluate the relationship between serum levels of advanced glycation end products (AGEs) and abdominal aortic calcification (AAC) in patients with type 2 diabetes mellitus (DM2). This was a prospective cross-sectional study. One-hundred and four consecutive patients with DM2 were given lateral lumbar X-rays in order to quantify abdominal aortic calcification (AAC
IJERPH | Special Issue : Diabetes Complications—from Childhood to - Medical care for geriatric patients is a great challenge, mainly due to various overlapping deficits relevant to numerous coexisting diseases, of which the most common are diabetes mellitus and atherosclerosis. In the case of diabetes, the glycation process is intensified, which accelerates atherosclerosis development and diabetic complications
Inflammation and Atherosclerosis | Circulation - These observations have considerable importance because, as discussed above, adipocytes can produce inflammatory cytokines, and a common underlying disorder of innate immunity may well link obesity, accelerated atherosclerosis, and insulin resistance. 71b In support of this hypothesis, very recent observations show that elevated levels of both
The Glycation Hypothesis of Atherosclerosis (Medical Intelligence Unit - The Glycation Hypothesis of Atherosclerosis (Medical Intelligence Unit): 9781570594441: Medicine & Health Science Books @
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- The formation of advanced glycation end-products (AGEs) correlates with glycemic control. The AGE hypothesis proposes that accelerated chemical modification of proteins by glucose during hyperglycemia contributes to the pathogenesis of diabetic complications including nephropathy, retinopathy, neuropathy and atherosclerosis
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Glycation, carbonyl stress, EAGLEs, and the vascular - The "glycation hypothesis'' has developed over the past 30 years, evolving gradually into a "carbonyl stress hypothesis'' and taking into account not only the modification of proteins by glucose, but also the roles of oxidative stress, a wide range of reactive carbonyl-containing intermediates (derived not only from glucose but also from lipids
The Glycation Hypothesis of Atherosclerosis (Medical - The Glycation Hypothesis of Atherosclerosis (Medical Intelligence Unit): 9781570594441: Medicine & Health Science Books @
Glycation - an overview | ScienceDirect Topics - Glycation refers to the irreversible binding of glucose with proteins and lipids and is an important factor in the pathogenesis of atherosclerosis. Understanding the process of glycation leads to greater insight into mechanistic link between glycation, CVD, and cognitive deficits
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Glycation - an overview | ScienceDirect Topics - What is glycation in chemistry?
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Atherosclerosis and glycation - PubMed - The proposed role of glycation in the pathogenesis of atherosclerosis would explain its high incidence among diabetics and the contentious epidemiological and experimental correlations between dietary sugar and atherosclerosis. Publication types Review MeSH terms Arteriosclerosis / etiology*
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- The formation of advanced glycation end-products (AGEs) correlates with glycemic control. The AGE hypothesis proposes that accelerated chemical modification of proteins by glucose during hyperglycemia contributes to the pathogenesis of diabetic complications including nephropathy, retinopathy, neuropathy and atherosclerosis
The glycation hypothesis of atherosclerosis (1997 edition - The glycation hypothesis of atherosclerosis by Camilo A. L. S. Colaco, 1997, Chapman & Hall, Landes Bioscience edition, in English The glycation hypothesis of atherosclerosis (1997 edition) | Open Library