Thesis M.Sc.University of Western Ontario Vincent Paul John Lemieux

The Effects of Dipyridamole on the Oxygen Paradox and Reactive Hyperemia [microform] by Vincent Paul

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The Effects of Dipyridamole on the Oxygen Paradox and Reactive Hyperemia [microform]

Author : Vincent Paul John Lemieux

Publisher : Thesis (M.Sc.)--University of Western Ontario

Published : 1970

ISBN-10 :

ISBN-13 :

Number of Pages : Pages

Language : en

Descriptions The Effects of Dipyridamole on the Oxygen Paradox and Reactive Hyperemia [microform]

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Results The Effects of Dipyridamole on the Oxygen Paradox and Reactive Hyperemia [microform]

The Effect of Dipyridamole on The Metabolism of Cardiac Muscle - The relationship between the metabolic and inotropic effect of dipyridamole on in vitro preparations of cat papillary and left atrial muscles was investigated. The oxygen consumption, contractility, glycogen content and energy-rich phosphate levels were used as parameters. They were measured by techniques previously described by Lee et at. (1960). Dipyridamole had no effect on the oxygen

Dipyridamole inhibits hydroxylamine augmented nitric oxide (NO ... - PubMed - Several drugs were tested so far in order to affect PMN function. It was demonstrated that dipyridamole (2,6-bis-diethanolamino-4,8-dipiperidinopyrimido-(5,4-d)-pyrimidine) can influence neutrophil function by inhibiting adenosine uptake. However, this action can not fully explain all of the observed effects of dipyridamole action on PMN

Dipyridamole increases oxygen-glucose deprivation-induced injury in - Lobner and Choi Dipyridamole Increases Neuronal Injury 2087 Sham -02/Glc Wash FIG 2. Effects o Af adenosin1 receptoer antagonist 8-cyclopen-tyltheophylline (8-CPT) (10 ^.mol/L) during oxygen-glucose de-privation. Experiments were performed using 45 minutes of oxygen-glucose deprivation, as this was a time that induced intermediate levels of damage

PDF The Association of Dipyridamole Side Effects with Hemodynamic - reaction to dipyridamole were 10% more liable to show an abnormal perfusion examination outcome (14). Meyers et al. have also described headache as being the most prev-alent adverse effect of dipyridamole in patients undergoing dual-isotope 201Tl rest/99mTc-sestamibi stress imaging (15). Laarman et al. have shown that low-level exercise during

The Effect of Dipyridamole on Vascular Cell-Derived Reactive Oxygen Species - At therapeutically relevant concentrations, dipyridamole suppresses the formation of ROS in platelets and endothelial cells and improves cellular redox status and suggest that the redox-dependent properties of dipyridine have a direct effect on vascular cells. Platelet and vascular stimulation leads to release of reactive oxygen species (ROS) that are known to influence vascular reactivity and

Inhibitory effect of dipyridamole and its derivatives on lipid ... - PubMed - Dipyridamole (DIP), 2,6-bis (diethanolamino)-4,8-dipiperidino- [5,4-d] pyrimidine, is a coronary vasodilator widely used in clinics. It has also been reported to have coactivator activity for a number of antitumour drugs and antioxidant activity in membrane systems. In recent years we have been studying the spectroscopic properties of this drug

Effects of dipyridamole and nitroprusside on the oxygen paradox and - Effects of dipyridamole and nitroprusside on the oxygen paradox and reactive hyperemia (Q71432894 ... Also known as; English: Effects of dipyridamole and nitroprusside on the oxygen paradox and reactive hyperemia. scientific article published on 01 February 1970. Statements. instance of. scholarly article. 1 reference. stated in. Europe PubMed

Paradoxical Reaction - an overview | ScienceDirect Topics - When a paradoxical reaction occurs during antibiotic treatment, culture for M. ulcerans may still be positive but after an 8-week course of antibiotics cultures are usually negative. A distinction has to be made between paradoxical reaction, recurrence (culture positive), and reinfection, that is a new episode of infection

Effects of dipyridamole and nitroprusside on the oxygen paradox and - Effects of dipyridamole and nitroprusside on the oxygen paradox and reactive hyperemia

Dipyridamole Side Effects: Common, Severe, Long Term - - Along with its needed effects, dipyridamole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. ... Allergic reaction, urticaria, pruritus, dermatitis, rash . Psychiatric. Uncommon (0.1% to 1%): Nervousness/anxiety. Rare (less than 0.1%): Depersonalization

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(PDF) Effect of Dipyridamole on the Reactive Oxygen Species and - To investigate the effects of dipyridamole (DPD) on the production of reactive oxygen species (ROS) and oxidative stress in cultured human trabecular meshwork cells (HTMC)

Dipyridamole: a medicine used to help prevent blood clots - NHS - The main side effects of dipyridamole are feeling or being sick, headaches and diarrhoea. You can drink alcohol with dipyridamole. However, do not drink too much while taking this medicine. ... Serious allergic reaction. In rare cases, dipyridamole can cause a serious allergic reaction (anaphylaxis). Immediate action required: Call 999 or go to

Dipyridamole - an overview | ScienceDirect Topics - Dipyridamole is used with 201 thallium imaging in the detection of coronary artery disease, but can cause dysrhythmias.. A 41-year-old man with hypertension was investigated for chest tightness by dipyridamole-thallium single-photon emission computed tomography [10].A standard dose of dipyridamole (0.56 mg/kg) was infused intravenously over 4 minutes, during which his heart rate increased

Paradoxical reaction - Wikipedia - A paradoxical reaction (or paradoxical effect) is an effect of a chemical substance, such as a medical drug, that is opposite to what would usually be expected. An example of a paradoxical reaction is pain caused by a pain relief medication. Paradoxical reactions may be more common in people with ADHD. [1]

The influence of dipyridamole and its derivatives on the membrane - The effect of dipyridamole on active oxygen generation by human polymorphonuclear leukocytes (PMN) was investigated. ... 5alpha-hydroperoxide of cholesterol which is only produced by reaction with

Dipyridamole Uses, Side Effects & Warnings - - Dipyridamole side effects. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Dipyridamole may cause serious side effects. Call your doctor at once if you have: a light-headed feeling, like you might pass out; chest pain; or

Dipyridamole - an overview | ScienceDirect Topics - Dipyridamole (8.1.73) is an FDA approved pyrimidine-based drug with antiplatelet and vasodilation activity. The drug inhibits adenosine reuptake and acts as a phosphodiesterase inhibitor which is also useful in the treatment of thrombo-embolic disorders when given with other anticoagulants. Dipyridamole also acts as a coronary vasodilator via

Inhibition of active oxygen generation by dipyridamole in human - The effect of dipyridamole on active oxygen generation by human polymorphonuclear leukocytes (PMN) was investigated. ... centre of these amines maintained the hydroxyl radical scavenging properties with triethanolamine having the greatest effect. The reactions and their pharmaceutical implications are discussed. Extensions of this work to

Understanding the Paradoxical Effect - Renaissance Recovery - The paradoxical effect can occur in a wide range of drug classes, including: Benzodiazepines. Stimulants. Barbiturates. Neurosteroids. Alcohol. inhalational anesthetics. Propofol. An evidence base shows that some paradoxical drug reactions are common, while others appear in single case reports

Adverse Reactions to Dipyridamole in Patients Undergoing Stress/Rest - Objective: A reaction scale was used to assess noncardiac adverse reactions exhibited by nuclear medicine outpatients receiving intravenous dipyridamole for pharmacological stress testing. Methods: The study included 933 patients referred to 2 cardiac outpatient centers for assessment. All patients evaluated in this study were unable to perform treadmill stress testing and underwent

Effect of Dipyridamole on the Reactive Oxygen Species and Oxidative - PURPOSE To investigate the effects of dipyridamole (DPD) on the production of reactive oxygen species (ROS) and oxidative stress in cultured human trabecular meshwork cells (HTMC). METHODS: Antioxidant activity of DPD was determined by DPPH assay

KoreaMed Synapse - Effect of Dipyridamole on the Reactive Oxygen Species and Oxidative Stress in Trabecular Meshwork Cells. Keun Woo Lee, MD, Jae Woo Kim, MD, PhD. Department of Ophthalmology, Catholic University of Daegu School of Medicine, Daegu, Korea

Effects of dipyridamole on myocardial adenosine and active ... - PubMed - Dipyridamole, a vasodilator that potentiates the actions of exogenous adenosine, is known to inhibit cellular uptake of adenosine, but its effects on cellular adenosine release, and thus interstitial adenosine levels, are disputed. We used the accumulation of adenosine in pericardial infusates (PCI) as an index of interstitial adenosine

Role of Adenosine and Nitric Oxide on the Mechanisms of Action of - The addition of dipyridamole to aspirin has been found to provide a greater protective effect in the secondary prevention of stroke compared with aspirin alone. 1 The molecular mechanism of action of dipyridamole is not completely understood and may be multiple. Dipyridamole inhibits the nucleoside transporter responsible for the cellular uptake of adenosine. 2 This transporter explains the

The Effect of Dipyridamole on Vascular Cell-Derived Reactive Oxygen - Platelet and vascular stimulation leads to release of reactive oxygen species (ROS) that are known to influence vascular reactivity and thrombosis. Dipyridamole is a vasodilator and platelet inhibitor that has previously been shown to have direct antioxidant properties. The antioxidant effects of dipyridamole on vascular cell-derived ROS are not known; therefore, dipyridamole was incubated

The Association of Dipyridamole Side Effects with Hemodynamic - Dipyridamole has extensively been administered as a substitute for physical activity in cardiovascular assessment. The aim of this study was to evaluate the association of dipyridamole side effects with hemodynamic oscillations, scanning results, and electrocardiography (ECG) findings. Methods: Overall, 590 patients referred to the nuclear medicine center for myocardial perfusion imaging were

The effect of dipyridamole on vascular cell-derived reactive oxygen - Platelet and vascular stimulation leads to release of reactive oxygen species (ROS) that are known to influence vascular reactivity and thrombosis. Dipyridamole is a vasodilator and platelet inhibitor that has previously been shown to have direct antioxidant properties. The antioxidant effects of dipyridamole on vascular cell-derived ROS are

Dipyridamole increases oxygen-glucose deprivation-induced injury in - Background and purpose: Adenosine transport inhibitors attenuate ischemic central neuronal damage in vivo, but the locus of this protective action is presently unknown. To help address the question of whether adenosine transport inhibitors have a protective effect directly on brain parenchyma, we tested the effect of the adenosine transport inhibitor dipyridamole on neuronal loss induced by

Effects of dipyridamole and nitroprusside on the oxygen - Effects of dipyridamole and nitroprusside on the oxygen paradox and reactive hyperemia

Adverse reactions to dipyridamole in patients undergoing - The most prevalent adverse reaction was headache (224 reactions; 37.1%), followed by chest pain (73 reactions; 12.1%), and nausea (67 reactions; 11.1%). A sex comparison revealed 271 of 454 male patients (59.7%) and 249 of 479 female patients (52%) demonstrated no adverse reaction to intravenous dipyridamole

Adverse reactions to dipyridamole in patients undergoing stress/rest ca… - What is the most common adverse reaction to dipyridamole?

Adverse Reactions to Dipyridamole in Patients Undergoing - mon noncardiac side effects of dipyridamole in nuclear med-icine cardiac patients demonstrated the most prevalent ad-verse reaction was headache. Analysis by sex revealed that signiﬁcantly more females than males complained of head-aches. Key Words: dipyridamole; pharmacological stress testing; 99mTc-sestamibi; 201Tl; noncardiac side effects

The effect of dipyridamole on vascular cell-derived reactive - Platelet and vascular stimulation leads to release of reactive oxygen species (ROS) that are known to influence vascular reactivity and thrombosis. Dipyridamole is a vasodilator and platelet inhibitor that has previously been shown to have direct antioxidant properties