Molecular and Cellular Analysis of Cell Death and Drug Resistance by Controlled Expression of Genes

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Molecular and Cellular Analysis of Cell Death and Drug Resistance by Controlled Expression of Genes that Influence Drug Actions Or Cell Death

Author : Dong Xu Yin

Publisher : Stanford University

Published : 1995

ISBN-10 :

ISBN-13 :

Number of Pages : 228 Pages

Language : en

Descriptions Molecular and Cellular Analysis of Cell Death and Drug Resistance by Controlled Expression of Genes that Influence Drug Actions Or Cell Death

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Results Molecular and Cellular Analysis of Cell Death and Drug Resistance by Controlled Expression of Genes that Influence Drug Actions Or Cell Death

Cellular Analysis - Enzo Life Sciences - A distinctive combination of reagents comprised of exceptional fluorescent molecular probes including CELLESTIAL® dyes for live, fixed and permeabilized cells. Products for drug discovery and research, in dynamic intracellular analysis with high spatial and temporal resolution for target, pathway and cell signaling analysis, reactive oxygen

Apoptosis - Enzo Life Sciences - Extrinsic. Simplistic. Of the three major established programmed cell death (PCD) pathways, Apoptosis (PCD Type 1) is the most-well characterized, being recognized as a critical regulator of development, immunity, as well as organ and tissue homeostasis. Apoptotic cells die in a controlled fashion in response to a variety of extrinsic or

Interception of Signaling Circuits of Esophageal Adenocarcinoma Cells - Here, we show the impact of resveratrol on the viability of the three adenocarcinoma esophageal cell systems studied, at the cellular level. Furthermore, an analysis at the molecular level revealed that the action was through the programmed cell death pathway, resulting in an increase in apoptotic and caspase-positive cells

Programmed cell death: molecular mechanisms and implications ... - PubMed - Apoptotic cell death may or may not require the activation of cytosolic proteases known as caspases. Autophagy (self-eating) has an important homeostatic role in the cell, mediating the removal of dysfunctional or damaged organelles thereby allowing the recycling of cellular building blocks. However, unrestrained autophagy can kill cells

Drug-Induced Death Signaling Strategy Rapidly Predicts Cancer ... - Cell - Early death signaling predicts cytotoxicity days before cell death occurs. •. Dynamic BH3 Profiling (DBP) is a functional measure of death signaling. •. DBP predicts response to targeted agents in vitro and in vivo. •. DBP is a potential tool for personalizing cancer therapy

XDeathDB: a visualization platform for cell death molecular - XDeathDB repository. XDeathDB cell death knowledge base contained human 27,654 genes, 149 cell death hallmark(key) genes, 1235 drug target genes, 2213 drugs, 164 signalling pathways, 12 cell death

Measurement and models accounting for cell death capture hidden - We assumed no cell death in the absence of drug to show the best-case scenario of assessing drug response. ... Two major phenotypic changes we can observe as cellular responses to drugs are cell

Drug GRADE: An Integrated Analysis of Population Growth and Cell Death - Anti-cancer drugs affect both the growth and survival of cancer cells. Commonly used measures of drug sensitivity do not distinguish between these two different outcomes. Schwartz et al. developed GRADE, a drug analysis method that reveals the proportional contributions of cell death versus growth inhibition for an observed drug response

Frontiers | Molecular mechanisms of programmed cell death in - 2.1.2 ER stress-induced apoptosis and METH neurotoxicity. According to growing evidence, METH-induced cell death can also be mediated by endoplasmic reticulum (ER) stress (Krasnova and Cadet, 2009; Yu et al., 2015; Yang et al., 2018).In addition to regulating protein folding and calcium signaling, the ER is a very important organelle for maintaining cellular homeostasis (Ferri and Kroemer, 2001)

Dissecting Programmed Cell Death with Small Molecules - ConspectusProgrammed cell death (PCD) is fundamentally an indispensable process in all cellular activities, including cell development, wound healing, and immune surveillance of tumors (Galluzzi, L. et al. Cell Death Differ. 2018, 25, 486−541). Malfunctioning of PCD has been shown to be closely related to human diseases such as acute pancreatitis, neurodegenerative diseases, and diverse

In Vitro Cell Death Determination for Drug Discovery: A Landscape - Thus, cell death-related assays are of primary importance in the field of oncology for drug discoveries. 1. Obviously, cell death is not unequivocal and can occur through many options. 2 Beyond semantic reasons, the ability to distinguish all forms of cell death is also clinically relevant to develop specific therapeutic drugs suitable for

Dissecting Programmed Cell Death with Small Molecules - Programmed cell death (PCD) is fundamentally an indispensable process in all cellular activities, including cell development, wound healing, and immune surveillance of tumors (Galluzzi, L. et al. Cell Death Differ. 2018, 25, 486-541). Malfunctioning of PCD has been shown to be closely related to human diseases such as acute pancreatitis, neurodegenerative diseases, and diverse types of cancers

DrugCell | Ideker Lab Project Page - DrugCell is a "visible" neural network (VNN) that predicts anti-cancer drug responses by modeling the hierarchical organization of a human cancer cell. Genotypes and drug structures induce differential patterns of activity on cellular subsystems, enabling in silico investigations of the molecular mechanisms underlying cancer drug response

Frontiers | Guidelines for Regulated Cell Death Assays: A Systematic - Introduction. Cell death is generally classified into two types: accidental cell death (ACD) and regulated cell death (RCD). RCD is regarded as reversible and can be blocked by small inhibitors (Wang S. et al., 2017; Cheng et al., 2018; Kumar and Sandhir, 2018; Wang et al., 2019c, d).Various programs of RCD have been described and their research continues to progress, including apoptosis

XDeathDB: a visualization platform for cell death molecular - To interpret the molecular mechanism of cell death modes comprehensively and their crosstalk knowledge and support medical research, genome analysis, systems biology, and education, we developed

Cell death assays for drug discovery - PubMed - Cell death has an important role in many human diseases, and strategies aimed at modulating the associated pathways have been successfully applied to treat various disorders. Indeed, several clinically promising cytotoxic and cytoprotective agents with potential applications in cancer, ischaemic and …

Apoptosis - Enzo Life Sciences - Monitor programmed cell death from membrane to nucleus - Of the three major established programmed cell death (PCD) pathways, Apoptosis (PCD Type 1) is the most-well characterized, being recognized as a critical regulator of development, immunity, as well as organ and tissue homeostasis

Cellular Analysis - Enzo Life Sciences - With over 2000 products for the analysis of cell death, Enzo enables detection of phenotypic hallmarks of apoptotic cell death. Detect Hallmarks Of Apoptosis Wide range of products for the study of Membrane Display Of Phosphatidylserine, Chromatin Condensation, DNA Damage

Dissecting Programmed Cell Death with Small Molecules - Programmed cell death (PCD) is fundamentally an indispensable process in all cellular activities, including cell development, wound healing, and immune surveillance of tumors (Galluzzi, L. et al. Cell Death Differ. 2018, 25, 486−541). Malfunctioning of PCD has been shown to be closely related to human diseases such as acute pancreatitis

Measurement and models accounting for cell death capture - Two major phenotypic changes we can observe as cellular responses to drugs are cell growth and death. Each response differs according to the administered drug and contributes to the overall effect