Assessment of a Role for Intracellular Mg2+ in the Regulation of Intracellular Ca2+ and Uridine Upta

Get Access Assessment of a Role for Intracellular Mg2+ in the Regulation of Intracellular Ca2+ and Uridine Uptake in Balb/c 3T3 Cells by Charles Andrew Vidair eBook in format PDF,ePub,Kindle and Audiobook

Assessment of a Role for Intracellular Mg2+ in the Regulation of Intracellular Ca2+ and Uridine Uptake in Balb/c 3T3 Cells

Author : Charles Andrew Vidair

Publisher : University of California, Berkeley

Published : 1982

ISBN-10 :

ISBN-13 :

Number of Pages : 456 Pages

Language : en

Descriptions Assessment of a Role for Intracellular Mg2+ in the Regulation of Intracellular Ca2+ and Uridine Uptake in Balb/c 3T3 Cells

Keyword :

Read Online Assessment of a Role for Intracellular Mg2+ in the Regulation of Intracellular Ca2+ and Uridine Uptake in Balb/c 3T3 Cells pdf

Download Assessment of a Role for Intracellular Mg2+ in the Regulation of Intracellular Ca2+ and Uridine Uptake in Balb/c 3T3 Cells epub

Assessment of a Role for Intracellular Mg2+ in the Regulation of Intracellular Ca2+ and Uridine Uptake in Balb/c 3T3 Cells Audiobook Download

Listen Assessment of a Role for Intracellular Mg2+ in the Regulation of Intracellular Ca2+ and Uridine Uptake in Balb/c 3T3 Cells book

Download Assessment of a Role for Intracellular Mg2+ in the Regulation of Intracellular Ca2+ and Uridine Uptake in Balb/c 3T3 Cells Audiobook

An electronic book, also known as an e-book or eBook, is a book publication made available in digital form, consisting of text, images, or both, readable on the flat-panel display of computers or other electronic devices. Although sometimes defined as "an electronic version of a printed book",some e-books exist without a printed equivalent. E-books can be read on dedicated e-reader devices, but also on any computer device that features a controllable viewing screen, including desktop computers, laptops, tablets and smartphones.

Results Assessment of a Role for Intracellular Mg2+ in the Regulation of Intracellular Ca2+ and Uridine Uptake in Balb/c 3T3 Cells

Figure 1 from The Involvement of Mg2+ in Regulation of Cellular and - Figure 1: Regulation of mitochondrial functions by Mg2+. Mitochondrial Mg2+ activates (————>) three dehydrogenases in the mitochondrial matrix: pyruvate dehydrogenase (conversion of mitochondrial pyruvate to acetyl coenzyme A), isocitrate dehydrogenase (conversion of isocitrate to 2-oxoglutarate), and 2-oxoglutarate dehydrogenase (conversion of 2-oxoglutarate to succinyl coenzyme A)

Overview of cell physiology of Mg 2+ . The intracellular Mg 2+ plays - The properties of Mg 2+ for interacting with numerous biomolecules render versatile roles, , a modulator of enzymatic activities, cell protection against cellular stress, channel regulation

Figure 2 from Magnesium Is a Key Player in Neuronal Maturation and - Figure 2. Intracellular Mg2+ distribution and machinery for Mg2+ regulation: The intracellular Mg2+ content is regulated by the balance of influx, efflux, and the intracellularly stored amount. Major storages for intracellular Mg2+ are the nuclei, mitochondria, ERs, and the ribosome. Cytosolic Mg2+ is bound to phosphometabolites, such as ATP. NIPA1, NIPA2, NIPA3, NIPA4, MagT1, TRPM6, TRPM7 and

An RNA Sensor for Intracellular Mg2+: Cell - Most RNA molecules require Mg2+ for their structure and enzymatic properties. Here we report the first example of an RNA serving as sensor for cytoplasmic Mg2+. We establish that expression of the Mg2+ transporter MgtA of Salmonella enterica serovar Typhimurium is controlled by its 5′ untranslated region (5′UTR). We show that the 5′UTR of the mgtA gene can adopt different stem-loop

Intracellular free Mg2+ and MgATP2- in coordinate control of protein - Intracellular free Mg 2+ determines the onset of protein synthesis in activated frog oocytes and its rate in lymphocytes. Mg 2+ regulation of protein synthesis is effected through the PI 3-K pathway at mTOR ... Mg 2+ and MgATP 2-apparently play a central role in the regulation of metabolism in a wide variety of cells and developmental stages

Magnesium and cell proliferation - PubMed - Although studies in mammalian cells and yeast suggest that Mg2+ plays an important role in cell growth and hormone response, intracellular roles of Mg2+ are poorly understood. Thus, we are developing methods to study Mg2+ regulation of growth and hormonal response. Preliminary data using cell-permea …

The role of Mg2+ in immune cells - - The role of Mg2+ in immune cells. The role of Mg2+ in immune cells. ... Depletion of intracellular Mg(2+) is a well-known phenomenon occurring after TBI and is associated with poor neurological outcome. ... that have been identified as potentially playing a role in regulating Mg(2+) homeostasis, although whether this role in magnesium

Laboratory Evaluation of Magnesium Status: Renal ... - ScienceDirect - The assessment of magnesium status is difficult because of the distribution of magnesium within the intracellular compartment. ... decrease Ca2+ conduction through Ca2+ channels, leading to smooth muscle relaxation, for example.72 Finally, intracellular Mg2+, through its role in activation of many enzymes, may affect signal

The Involvement of Mg2+ in Regulation of Cellular and Mitochondrial - Mg 2+ is an essential mineral with pleotropic impacts on cellular physiology and functions. It acts as a cofactor of several important enzymes, as a regulator of ion channels such as voltage-dependent Ca 2+ channels and K + channels and on Ca 2+-binding general, Mg 2+ is considered as the main intracellular antagonist of Ca 2+, which is an essential secondary messenger initiating

The Involvement of Mg2+ in Regulation of Cellular and Mitochondrial - In general, Mg 2+ is considered as the main intracellular antagonist of Ca 2+, which is an essential secondary messenger initiating or regulating a great number of cellular functions. This review examines the effects of Mg 2+ on mitochondrial functions with a particular focus on energy metabolism, mitochondrial Ca 2+ handling, and apoptosis. 1

Roles of Ca2+, Mg2+, and Ba2+ Cations in the Regulation of TRPV1 - In experiments performed on a primary culture of neurons isolated from the dorsal root ganglia (DRGs) of rats, we estimated the level of intracellular calcium using fluorescence microscopy and a fluorescent probe for divalent cations, Fura 2. It was found that capsaicin (Caps) affects the Ca2+ permeability of the plasmalemma and does not cause Ca2+ release from the intracellular stores. As

Intracellular magnesium: Transport and regulation in epithelial - Abstract. The mechanisms of magnesium (Mg2+) transport, the regulation of intracellular Mg2+ concentrations and the relationship between Mg2+ and Ca2+ signaling during the stimulus-secretion

GABA-Induced Intracellular Mg2 - ScienceDirect - Cells simultaneously utilize different intracellular signaling systems to process environmental information [1, 2, 3, 4].The magnesium ion (Mg 2+) is recognized as a multitarget analog regulator that performs many roles, such as circadian timekeeping, due to the following properties: (1) it influences wide-ranging biological processes, (2) its concentration is tightly controlled within a

(PDF) Mg2+ and Excitable Membranes - ResearchGate - Gradually, however, it is becoming clear that Mg2+ plays an important intracellular role: It is a co-factor in numerous enzymatic reactions, has a regulatory function on several ionic channels

Intracellular magnesium homeostasis - Magnesium in the Central Nervous - Magnesium (Mg2+) is the fourth most abundant cation in the whole body and the second most abundant cation within the cell. Numerous cellular functions and enzymes, including ion channels, metabolic cycles, and signalling pathways are regulated by Mg2+. Our understanding of how cells regulate Mg2+ homeostasis and transport has registered significant progress in recent time. Yet, several aspects

Regulation of Mg2+ Reabsorption and Transient Receptor ... - PubMed - Regulation of Mg2+ Reabsorption and Transient Receptor Potential Melastatin Type 6 Activity by cAMP Signaling ... a marker of the distal convoluted segment of the kidney, the principal site of TRPM6 expression. Given the critical role of TRPM6 in Mg(2+) reabsorption, an inducible kidney-specific Adcy3 deletion mouse model was characterized for

DISCUSSION: Magnesium in Regulation of Cellular and Mitochondrial - 1. Impact of Mg2+ on Cellular Functions and Intracellular Mg2+ Dynamics ///, Mg2+ alters the electrophysiological properties of ion channels such as voltage-dependent Ca2+ channels and K+ channels . The voltage-dependent block of N-methyl-D-aspartate receptor by Mg2+ [4, 5] represents an important phenomenon in the neurosciences

Mg2+ regulation of kinase signaling and immune function - Mg 2+ is required at micromolar concentrations as a cofactor for ATP, enzymatic reactions, and other biological processes. We show that decreased extracellular Mg 2+ reduced intracellular Mg 2+ levels and impaired the Ca 2+ flux, activation marker up-regulation, and proliferation after T cell receptor (TCR) stimulation. Reduced Mg 2+ specifically impairs TCR signal transduction by IL-2

Reduction of intracellular Mg2+ caused by reactive oxygen species in - The concentration of intracellular free Mg2+ ([Mg2+]i) should be maintained strictly for the regulation of cellular functions. Since reactive oxygen species (ROS) are liable to increase in various pathological conditions and induce cellular damage, we investigated whether ROS affect intracellular Mg2+ homeostasis. We measured [Mg2+]i in ventricular myocytes from Wistar rats using the

Intracellular Mg2+ and magnesium depletion in isolated renal thick - Magnesium reabsorption and regulation within the kidney occur principally within the cortical thick ascending limb (cTAL) cells of the loop of Henle. Fluorometry with the dye, mag-fura-2, was used to characterize intracellular Mg2+ concentration ([Mg2+]i) in single cTAL cells. Primary cell cultures …

[PDF] The Involvement of Mg2+ in Regulation of Cellular and - In general, Mg2+ is considered as the main intracellular antagonist of Ca2+, which is an essential secondary messenger initiating or regulating a great number of cellular functions. This review examines the effects of Mg2+ on mitochondrial functions with a particular focus on energy metabolism, mitochondrial Ca2+ handling, and apoptosis

The assessment of intracellular magnesium: different strategies to - The role of magnesium in cell metabolism is complex and still not completely clarified. Although magnesium has been shown to modulate many phenomena in cells, its intracellular distribution and

Central Roles of Mg2+ and MgATP2− in the Regulation of Protein - It plays a role in tumor biology via the regulation of ... recent results regarding the roles of intracellular Mg2+ and its regulatory system in determining the cell phenotype, fate, and diseases

Intracellular free magnesium and its regulation, studied in isolated - Intracellular free magnesium ([Mg2+]i) was measured in isolated ferret papillary muscles using ion-selective microelectrodes filled with the new magnesium sensor ETH 5214. ... Ca2+ from 20 microM to around 10 nM also did not affect the response so these electrodes are ideally suited to study intracellular Mg2+ and its regulation. The mean value

Intracellular magnesium: transport and regulation in epithelial - Abstract. The mechanisms of magnesium (Mg2+) transport, the regulation of intracellular Mg2+ concentrations and the relationship between Mg2+ and Ca2+ signaling during the stimulus-secretion coupling process in pancreatic acinar cells and other secretory epithelia are reviewed in this article. Our results demonstrate the existence of a Na+- and

The primary role of intracellular free Mg2+ in regulating cell growth - central role in the regulation of metabolism and proliferation in both systems. A third system that indicates the gen-erality of the regulatory role is the activa-tion of protein synthesis in frog oocytes by of importance to compare side-by-side, using the very same tissues samples, the classic method of vindeløv et al.,8 with the approach

PDF The role of Mg2+ in immune cells - Springer - regulation of intra- and extracellular Mg2? levels and the biological role of these proteins in the immune context. Mg2? is the most abundant divalent cation in cells with a total cellular concentration between 14 and 20 mM [4]. Within mammalian cells, hundreds of different enzymes, beyond those involved in metabolic cycles, are required and

Myoplasmic free Mg2+ concentration during repetitive stimulation of - The role of the myoplasmic free Mg2+ concentration ([Mg2+]i) in fatigue was studied in intact single fibres isolated from mouse skeletal muscle. ... Injection of MgCl2 was also used to assess the intracellular Mg2+ buffering. The mean Mg2+ buffer power ( the ratio of the change in [Mg2+]i to the amount of Mg2+ added) was 0.62

(PDF) The Involvement of Mg 2+ in Regulation of Cellular and - In general, Mg ²⁺ is considered as the main intracellular antagonist of Ca ²⁺ , which is an essential secondary messenger initiating or regulating a great number of cellular functions

The primary role of intracellular free Mg2+ in regulating - strong case for a central role of Mg2+ in growth regulation. Further experimental work on the Mg2+ 2+ regulation of protein synthesis and cell pro-liferation in fibroblasts through physiologi-cal means was virtually non-existent beyond the early 1980s. But a molecular genetic approach was developed in an established

- For purposes of discussion, four criteria have been developed that should be fulfilled if Mg2+ is to be accepted as an important intracellular regulatory cation: cellular processes must exist which are sensitive to free Mg2+ within the physiological concentration range; a (transport) mechanism(s) must exist which is capable of altering free Mg2+ concentration within a cell; if Mg2+ is compartmented within cells, any potentially regulated system or process and any change in intracellular

Magnesium in the Central Nervous System - NCBI Bookshelf - Regulation of Mg2+transport and homeostasis Serum Mg2+level and Mg2+sensing mechanism Physiological role of intracellular Mg2+ Ca2+- and K+-channels Conclusions References Magnesium transport across the blood-brain barriers Mounir N. Ghabriel and Robert Vink. Abstract Introduction Magnesium absorption and excretion

Magnesium and the heart: Antiarrhythmic therapy with magnesium - The cardiac electrophysiological role and characteristics of Mg2+ at a cellular level are less familiar than those of K, but it is known that the functions of the two cations are closely re- lated.3,9 Potassium loss by the myocardial cells is almost al- ways accompanied by Mg2+ depletion, and hypomagnesemia

The Involvement of Mg2+ in Regulation of Cellular and - Mg 2+ is an essential mineral with pleotropic impacts on cellular physiology and functions. It acts as a cofactor of several important enzymes, as a regulator of ion channels such as voltage-dependent Ca 2+ channels and K + channels and on Ca 2+ -binding proteins

Intracellular magnesium homeostasis - Magnesium in the - While the increasing number of observations supports a key regulatory role for Mg2+within the cell, our understanding of how Mg2+homeostasis is regulated at the cellular and subcellular level remains sketchy and incomplete. There are both conceptual and methodological reasons for this limitation