Gene Therapy for Cartilage and Bone Tissue Engineering by Yu-Chen Hu

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Gene Therapy for Cartilage and Bone Tissue Engineering

Author : Yu-Chen Hu

Publisher : Springer Berlin Heidelberg

Published : 2014-01-29

ISBN-10 : 3642539246

ISBN-13 : 9783642539244

Number of Pages : 89 Pages

Language : en

Descriptions Gene Therapy for Cartilage and Bone Tissue Engineering

"Gene Therapy for Cartilage and Bone Tissue Engineering" outlines the tissue engineering and possible applications of gene therapy in the field of biomedical engineering as well as basic principles of gene therapy, vectors and gene delivery, specifically for cartilage and bone engineering. It is intended for tissue engineers, cell therapists, regenerative medicine scientists and engineers, gene therapist and virologists. Dr. Yu-Chen Hu is a Distinguished Professor at the Department of Chemical Engineering, National Tsing Hua University and has received the Outstanding Research Award (National Science Council), Asia Research Award (Society of Chemical Engineers, Japan) and Professor Tsai-Teh Lai Award (Taiwan Institute of Chemical Engineers). He is also a fellow of the American Institute for Medical and Biological Engineering (AIMBE) and a member of the Tissue Engineering International & Regenerative Medicine Society (TERMIS)-Asia Pacific Council.

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Results Gene Therapy for Cartilage and Bone Tissue Engineering

Gene Therapy to Enhance Bone and Cartilage Repair in ... - PubMed - Gene Therapy to Enhance Bone and Cartilage Repair in Orthopaedic Surgery Curr Gene Ther. 2018;18(3) :154-170. ... Tissue engineering via gene therapy attempts to provide an alternative treatment strategy to address the deficits associated with conventional approaches. The transfer of specific target genes coding for proteins with therapeutic or

Genipin-Crosslinked Chitosan Gels and Scaffolds for Tissue Engineering - The present review article intends to direct attention to the technological advances made since 2009 in the area of genipin-crosslinked chitosan (GEN-chitosan) hydrogels. After a concise introduction on the well recognized characteristics of medical grade chitosan and food grade genipin, the properties of GEN-chitosan obtained with a safe, spontaneous and irreversible chemical reaction, and

Detection of Mulatexin in Local Mulberry Plants (Morus spp.) from Bogor - The mlx56 gene family is found exclusively in the mulberry (Morus spp.) plant, and its role is to defend against insect herbivores, yet it had never been discovered from Indonesia, which has been cultivating mulberry silkworm's (Bombyx mori) feed in order to produce silks. This research focused on studying the expression of mlx56 gene family in local mulberry plants from Bogor, West Java

William Ben Gunawan - Business Development - VSPN | LinkedIn - A Bachelor of Nutrition graduated from Diponegoro University, Indonesia. I'm interested in functional food, gut microbiota, and the relationship between nutrition and ageing process. I've published a handful of my research papers in reputable international journals. While actively endeavoring to create more research ideas and publications, I also enjoy discussing about investment (mutual funds

Gene Therapy for Cartilage and Bone Tissue Engineering - Apple Books - "Gene Therapy for Cartilage and Bone Tissue Engineering" outlines the tissue engineering and possible applications of gene therapy in the field of biomedical engineering as well as basic principles of gene therapy, vectors and gene delivery, specifically for cartilage and bone engineering. It is intended for tissue engineers, cell therapists

In-depth study of bio-oil and biochar production from macroalgae - Sargassum is undoubtedly one of the most predominant brown macroalgae, posing a significant disposal problem for coastal areas worldwide. The effective valorization of Sargassum sp. would be beneficial not only for environmental mitigation but also for producing high-value chemicals. However, the valorization of Sargassum sp. for bio-oil and biochar production via slow pyrolysis has not been

Gene Therapy to Enhance Bone and Cartilage Repair in Orthopaedic - Keywords: Gene therapy, Viral vectors, Tissue engineering, Bone healing, Cartilage repair, Osteoarthritis. Abstract: Musculoskeletal conditions are a major public health problem. Approximately 66 million individuals seek medical attention for a musculoskeletal injury in the United States, with current medical costs being estimated at $873

Gene Therapy for Cartilage and Bone Tissue Engineering by Yu ... - eBay - Entdecke Gene Therapy for Cartilage and Bone Tissue Engineering by Yu-Chen Hu (English) P in großer Auswahl Vergleichen Angebote und Preise Online kaufen bei eBay Kostenlose Lieferung für viele Artikel!

Cell and Tissue Engineering | Biomedical Engineering - Cell and tissue engineering includes the study of cellular mechanics and cell signaling, mechanotransduction, biosystems engineering and computational biology, nanotechnology, microfluidics, bioMEMS and gene chips, functional tissue engineering and biomaterials, tissue structure-function and cell-matrix interactions

Ultrasound-triggered Drug Delivery using Stimuli-responsive Hydrogels - In one study, Liu et al. proposed a novel design of injectable chemotaxis hydrogels to help promote the migration of bone marrow mesenchymal cells for cartilage repair. Other examples of using smart hydrogels and ultrasound in tissue engineering applications include cartilage repair [55] , bone repair [47] [56] , and wound healing [3]

Biology and therapeutic potential of mesenchymal stem cell - Recent developments in understanding the immunomodulatory and tissue-differentiating properties of mesenchymal stem cell (MSC) therapy have raised the possibility of applying such treatment to AxSpA

Engineering Inflammation-resistant cartilage: BRIDGING GENE THERAPY and - The lack of ideal treatment options for cartilage injuries motivated us to tissue engineer a cartilage tissue which would be more resistant to inflammation. A Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 knockout of TGF-β-activated kinase 1 (TAK1) gene in polydactyly chondrocytes provides multivalent protection

Ectopic chondrogenesis of nude mouse induced by nano gene delivery - In contrast, gene-enhanced tissue engineering technology has significantly more hope for cartilage repair. 48,49 To solve these problems, this study explored a new therapeutic approach for the treatment of cartilage defects using bone marrow stromal stem cells. Compared to the viral vectors, non-viral systems haveattracted significant attention

Nearly 150 genes involved in cartilage development may control human - Scientists have pinpointed 145 potential "height genes" in cells that make up the cartilage at the ends of children's bones and affect how tall they grow. These cartilage cells, known as chondrocytes, multiply and mature in areas of tissue called growth plates, which sit near the ends of long bones in children and teens and determine each bone

Gene therapy for repair and regeneration of bone and cartilage - Gene therapy refers to the use of viral and non-viral vectors to deliver nucleic acids to tissues of interest using direct (in vivo) or transduced cell-mediated ( ex vivo) approaches. Over the past few decades, strategies have been adopted to express therapeutic transgenes at sites of injury to promote or facilitate repair of bone and cartilage

Gene Therapy to Enhance Bone and Cartilage Repair in Orthopaedic - Title:Gene Therapy to Enhance Bone and Cartilage Repair in Orthopaedic Surgery. ... Tissue engineering via gene therapy attempts to provide an alternative treatment strategy to address the deficits associated with conventional approaches. The transfer of specific target genes coding for proteins with therapeutic or regenerative properties to

Cartilage and Bone Regeneration Using Gene-Enhanced Tissue E ... - LWW - gene therapy and tissue engineering were combined using a retroviral vector to stably introduce the human bone morphogenic protein-7 complementary deoxyribonucleic acid into periosteal-derived rabbit mesenchymal stem cells. Bone morphogenic protein-7 secreting gene modified cells subsequently were expanded in monolayer culture, seeded onto polyglycolic acid grafts, implanted into a rabbit knee

Gene Therapy for Cartilage Tissue Engineering | SpringerLink - Analogous to gene transfer for bone engineering, gene transfer for cartilage engineering can be mediated via GAM, yet in the context of cartilage repair the GAM is often seeded with cells for ex vivo gene delivery. ... Gene Therapy for Cartilage Tissue Engineering. In: Gene Therapy for Cartilage and Bone Tissue Engineering. SpringerBriefs in

Advances in Biomaterial-Mediated Gene Therapy for Articular Cartilage - The applications of gene therapy and tissue engineering have accelerated the therapeutic development of cartilage repair. Despite treatment, patients' outcomes are still affected by many other factors. ... Gene Delivery of TGF-beta3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue

Aysegul Atasoy-Zeybek () - Research Fellow - LinkedIn - The objective of this review is to highlight fundamental principles of gene therapy strategies in bone tissue engineering and solutions of their current limitations for the healing of bone injury

Biomaterial-guided delivery of gene vectors for targeted ... - Nature - Gene therapy and tissue engineering strategies for the treatment of cartilage repair each pose unique challenges to clinical translation. ... J. M. et al. Cartilage and bone regeneration using

Gene Therapy to Enhance Bone and Cartilage Repair in ... - PubMed - In preclinical studies, gene therapy has been successfully used to treat cartilaginous, bone, skeletal muscle, tendon, ligament and intervertebral disk injuries. In addition, gene therapy is being assessed in clinical trials for its safety and therapeutic potential in osteoarthritis

Gene Therapy for Cartilage Tissue Engineering | SpringerLink - Gene therapy has converged with cartilage engineering in recent years, by which an increasing number of therapeutic genes have been explored to stimulate cartilage repair. These genes can be administered to cells via in vivo or ex vivo approaches using either viral or nonviral vectors

- Gene therapy holds promise for the treatment of articular cartilage lesions by providing reparative gene sequences at sites of tissue injury. Tissue engineering approaches provide adapted scaffolding matrices that can support the mechanisms of cartilage repair

Biofunctional Materials for Bone and Cartilage Tissue Engineering - Cardiac tissue engineering (CTE) is a multi-disciplinary strategy that has been considered as a novel alternative approach for cardiac regenerative medicine and replacement therapies

Gene therapy for repair and regeneration of bone and cartilage - Gene therapy refers to the use of viral and non-viral vectors to deliver nucleic acids to tissues of interest using direct (in vivo) or transduced cell-mediated (ex vivo) approaches. Over the past few decades, strategies have been adopted to express therapeutic transgenes at sites of injury to promote or facilitate repair of bone and cartilage

Gene Therapy for Cartilage and Bone Tissue Engineering - Springer - "Gene Therapy for Cartilage and Bone Tissue Engineering" outlines the tissue engineering and possible applications of gene therapy in the field of biomedical engineering as well as basic principles of gene therapy, vectors and gene delivery, specifically for cartilage and bone engineering

Engineering Inflammation-resistant cartilage: BRIDGING GENE - A Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 knockout of TGF-β-activated kinase 1 (TAK1) gene in polydactyly chondrocytes provides multivalent protection against the signals that activate the pro-inflammatory and catabolic NF-κB pathway